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Article

Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.

Oncotarget - 21 Jun 2016

Tang Haiping, Chen Yuling, Liu Xiaohui, Wang Shiyu, Lv Yang, Wu Di, Wang Qingtao, Luo Minkui, Deng Haiteng

Abstract excerpt

In the present study, we demonstrate that HSP60 is unequivocally downregulated in clear cell renal cell carcinoma (ccRCC) tissues compared to pericarcinous tissues. Overexpression of HSP60 in ccRCC cancer cells suppresses cell growth. HSP60 knockdown increases cell growth and proliferation in both cell culture and nude mice xenografts, and drives cells to undergo epithelial to mesenchymal transition (EMT). Our...

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Identifiers

PMID: 27246978
DOI: 10.18632/oncotarget.9615
PMCID: PMC5122432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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