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Article

Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma.

Oncotarget - 1 Nov 2012

Sourbier Carole, Srivastava Gaurav, Ghosh Manik C, Ghosh Sanchari, Yang Youfeng, Gupta Gopal, Degraff William, Krishna Murali C, Mitchell James B, Rouault Tracey A, Linehan W Marston

Abstract excerpt

The tumor suppressor gene, Von Hippel-Lindau (VHL), is frequently mutated in the most common form of kidney cancer, clear cell renal cell carcinoma (CCRCC). In hypoxic conditions, or when there is a VHL mutation, the hypoxia inducible factors, HIF1α and HIF2α, are stabilized and transcribe a panel of genes associated with cancer such as vascular endothelial growth factor receptor (VEGFR), platelet derived growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23178531
DOI: 10.18632/oncotarget.561
PMCID: PMC3717806

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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