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A Nutrient-Deficient Microenvironment Facilitates Ferroptosis Resistance via the FAM60A–PPAR Axis in Pancreatic Ductal Adenocarcinoma

20 Dec 2023

Abstract excerpt

Ferroptosis, a nonapoptotic form of cell death, is an emerging potential therapeutic target for various diseases, including cancer. However, the role of ferroptosis in pancreatic cancer remains poorly understood. Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis and chemotherapy resistance, attributed to its high Kirsten rats arcomaviral oncogene homolog mutation rate and severe...

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PMID: 38314086
DOI: 10.34133/research.0300

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