Article
A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis.
Infection and immunity - 1 Aug 2016
Watanabe Shinya, Matsumura Kazunori, Iwai Hiroki, Funatogawa Keiji, Haishima Yuji, Fukui Chie, Okumura Kayo, Kato-Miyazawa Masako, Hashimoto Masahito, Teramoto Kanae, Kirikae Fumiko, Miyoshi-Akiyama Tohru, Kirikae Teruo
Abstract excerpt
Mycobacterium tuberculosis contains a single rRNA operon that encodes targets for antituberculosis agents, including kanamycin. To date, only four mutations in the kanamycin binding sites of 16S rRNA have been reported in kanamycin-resistant clinical isolates. We hypothesized that another mutation(s) in the region may dramatically decrease M. tuberculosis viability and virulence. Here, we describe an rRNA...
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