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Article

Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion.

Cellular & molecular biology letters - 1 Mar 2015

Kotkowska Agnieszka, Sewerynek Ewa, Domańska Daria, Pastuszak-Lewandoska Dorota, Brzeziańska Ewa

Abstract excerpt

STAT3 (signal transducer and activator of transcription 3) is an important cellular effector in the Jak/STAT signaling pathway, which plays a pivotal role in human immune system regulation, mediating the effect of different cytokines. In the present study, we assessed the correlation between STAT3 polymorphisms (rs3816769 C>T and rs744166 A>G) and risk of the autoimmune thyroid diseases (AITDs) Hashimoto's...

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Identifiers

PMID: 26204395
DOI: 10.1515/cmble-2015-0004

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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