Article
Association of functional GITR gene polymorphisms related to expression of glucocorticoid-induced tumour necrosis factor-receptor (GITR) molecules with prognosis of autoimmune thyroid disease.
Clinical and experimental immunology - 1 Aug 2011
Tomizawa R, Watanabe M, Inoue N, Takemura K, Hidaka Y, Akamizu T, Hayakawa K, Iwatani Y
Abstract excerpt
The glucocorticoid-induced tumour necrosis factor (TNF)-receptor (GITR) affects the functions of regulatory T (T(reg)) and effector T (T(eff)) cells, but the significance of this phenomenon is still unclear. To examine the association of single nucleotide polymorphisms (SNPs) in the GITR gene with the expression of GITR molecules on T cells and with the pathological conditions in patients with autoimmune thyroid...
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