Article

Vaccination by single dose sporozoite injection of blood stage attenuated malaria parasites

2023-10-24

Abstract excerpt

An efficient malaria vaccine remains elusive. As an alternative to malaria subunit vaccines, vaccination approaches are currently explored using live Plasmodium parasites, either attenuated mosquito-derived sporozoites or attenuated blood stage parasites. Both approaches would profit from the availability of attenuated and avirulent parasites with a reduced blood stage multiplication rate. Ideally, such slow grow...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 17b993ba-04ad-5ee4-b43c-81c6d6be1a00
DOI: 10.1101/2023.10.24.563045

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vaccination by single dose sporozoite injection of blood stage attenuated malaria parasitesDOI 10.1101/2023.10.24.563045Read

Protective efficacy and safety of liver stage attenuated malaria parasitesSemantic proximity Read

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletionSemantic proximity Read

Plasmodium yoelii as a model for malaria: insights into pathogenesis, drug resistance, and vaccine developmentSemantic proximity Read

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasiteSemantic proximity Read

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria InfectionSemantic proximity Read

A replication-competent late liver stage–attenuated human malaria parasiteSemantic proximity Read

Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoitesSemantic proximity Read

Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.Semantic proximity Read

Genetically engineered, attenuated whole-cell vaccine approaches for malariaSemantic proximity Read

Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liverSemantic proximity Read

Preerythrocytic, live-attenuated <i>Plasmodium falciparum</i> vaccine candidates by designSemantic proximity Read

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.Semantic proximity Read