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Article

Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma

9 Dec 2010

Abstract excerpt

Oral cancer is a highly aggressive malignancy with poor prognosis. This study examined the behaviour of fibroblast strains from normal oral mucosa, dysplastic epithelial tissue, and genetically stable (minimal copy number alterations-CNA; minimal loss of heterozygosity-LOH; wild-type p53; wild-type p16INK4A) and unstable (extensive CNA and LOH; inactivation of p53 and p16INK4A) oral squamous cell carcinoma...

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PMID: 21294120
DOI: 10.1002/path.2841

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