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Article

Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β.

Carcinogenesis - 1 Jun 2013

Hassona Yazan, Cirillo Nicola, Lim Kue Peng, Herman Andrew, Mellone Max, Thomas Gareth J, Pitiyage Gayani N, Parkinson E Ken, Prime Stephen S

Abstract excerpt

Keratinocyte senescence acts as a barrier to tumor progression but appears to be lost in late pre-malignancy to yield genetically unstable oral squamous cell carcinomas (GU-OSCC); a subset of OSCC possessing wild-type p53 and are genetically stable (GS-OSCC). In this study, fibroblasts from GU-OSCC were senescent relative to fibroblasts from GS-OSCC, epithelial dysplastic tissues or normal oral mucosa, as...

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PMID: 23358854
DOI: 10.1093/carcin/bgt035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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