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Article

Novel insertion mutation of ABCB1 gene in an ivermectin-sensitive Border Collie.

Journal of veterinary science - 1 Dec 2010

Han Jae-Ik, Son Hyoung-Won, Park Seung-Cheol, Na Ki-Jeong

Abstract excerpt

P-glycoprotein (P-gp) is encoded by the ABCB1 gene and acts as an efflux pump for xenobiotics. In the Border Collie, a nonsense mutation caused by a 4-base pair deletion in the ABCB1 gene is associated with a premature stop to P-gp synthesis. In this study, we examined the full-length coding sequence of the ABCB1 gene in an ivermectin-sensitive Border Collie that lacked the aforementioned deletion mutation. The...

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Source

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Identifiers

PMID: 21113104
DOI: 10.4142/jvs.2010.11.4.341
PMCID: PMC2998746

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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