Article
The FBPase Encoding Gene glpX Is Required for Gluconeogenesis, Bacterial Proliferation and Division In Vivo of Mycobacterium marinum.
PloS one - 1 Jan 2016
Tong Jingfeng, Meng Lu, Wang Xinwei, Liu Lixia, Lyu Liangdong, Wang Chuan, Li Yang, Gao Qian, Yang Chen, Niu Chen
Abstract excerpt
Lipids have been identified as important carbon sources for Mycobacterium tuberculosis (Mtb) to utilize in vivo. Thus gluconeogenesis bears a key role for Mtb to survive and replicate in host. A rate-limiting enzyme of gluconeogenesis, fructose 1, 6-bisphosphatase (FBPase) is encoded by the gene glpX. The functions of glpX were studied in M. marinum, a closely related species to Mtb. The glpX deletion strain...
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