Article
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.
Molecular microbiology - 1 Nov 2008
Sambou Tounkang, Dinadayala Premkumar, Stadthagen Gustavo, Barilone Nathalie, Bordat Yann, Constant Patricia, Levillain Florence, Neyrolles Olivier, Gicquel Brigitte, Lemassu Anne, Daffé Mamadou, Jackson Mary
Abstract excerpt
Mycobacterium tuberculosis and other pathogenic mycobacterial species produce large amounts of a glycogen-like alpha-glucan that represents the major polysaccharide of their outermost capsular layer. To determine the role of the surface-exposed glucan in the physiology and virulence of these bacteria, orthologues of the glg genes involved in the biosynthesis of glycogen in Escherichia coli were identified in M....
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