Article
Mammosphere-forming cells from breast cancer cell lines as a tool for the identification of CSC-like- and early progenitor-targeting drugs.
Cell cycle (Georgetown, Tex.) - 15 Jul 2010
Cioce Mario, Gherardi Simona, Viglietto Giuseppe, Strano Sabrina, Blandino Giovanni, Muti Paola, Ciliberto Gennaro
Abstract excerpt
Here we show that a subpopulation of MCF-7 breast cancer cells which stains pale to Toluidine Blue (Light Cells- LCs), is endowed with features of CSCs. LCs give rise to self-renewing mammospheres and express typical CSC markers; moreover this subpopulation is chemoresistant and highly tumorigenic in vivo. LCs can be identified in several other breast cancer cell lines, irrespectively of their histological origin...
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