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Article

Phenotypic Heterogeneity of Breast Cancer Stem Cells

1 Jan 2011

Abstract excerpt

Many types of tumors are organized in a hierarchy of heterogeneous cell populations, with only a small proportion of cancer stem cells (CSCs) capable of sustaining tumor formation and growth, giving rise to differentiated cells, which form the bulk of the tumor. Proof of the existence of CSC comes from clinical experience with germ-cell cancers, where the elimination of a subset of undifferentiated cells can cure...

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PMID: 21317983
DOI: 10.1155/2011/135039

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