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Article

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

The Journal of clinical investigation - 1 Aug 2011

Wang Hongwei, Venkatesh Madhukumar, Li Hao, Goetz Regina, Mukherjee Subhajit, Biswas Arunima, Zhu Liang, Kaubisch Andreas, Wang Lei, Pullman James, Whitney Kathleen, Kuro-o Makoto, Roig Andres I, Shay Jerry W, Mohammadi Moosa, Mani Sridhar

Abstract excerpt

The nuclear receptor pregnane X receptor (PXR) is activated by a range of xenochemicals, including chemotherapeutic drugs, and has been suggested to play a role in the development of tumor cell resistance to anticancer drugs. PXR also has been implicated as a regulator of the growth and apoptosis...

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Source

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Identifiers

PMID: 21747170
DOI: 10.1172/JCI41514
PMCID: PMC3148718

Genes

FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21747170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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