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Article

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

Pharmacogenetics and genomics - 1 Apr 2011

Giegling Ina, Drago Antonio, Dolžan Vita, Plesničar Blanka Kores, Schäfer Martin, Hartmann Annette M, Sander Thomas, Toliat Mohammad Reza, Möller Hans-Jürgen, Stassen Hans H, Rujescu Dan, Serretti Alessandro

Abstract excerpt

BACKGROUND: The glutamatergic system may be relevant to the pathophysiology of psychosis and to the effects of antipsychotic treatments. OBJECTIVES: We investigated a set of 62 SNPs located in genes coding for subunits of glutamatergic receptors (GAD1, GRIA1, GRIA3, GRIA4, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIN2B, GRM1 and GRM4), and the transporter of glycine (SLC6A5), as modulators of the effects of...

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Share to Antipsychotic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Haloperidol

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Glutamate

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Source

Identifiers

PMID: 20859245
DOI: 10.1097/FPC.0b013e32833efb18

Genes

GAD1
GRIA1
GRIA3
GRIA4
GRID2
GRIK1
GRIK2
GRIK3
GRIK4
GRM1
GRM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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