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Article

Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations.

Journal of cellular and molecular medicine - 1 Oct 2016

Song Pu, Li Kai, Liu Ling, Wang Xiaowen, Jian Zhe, Zhang Weigang, Wang Gang, Li Chunying, Gao Tianwen

Abstract excerpt

The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress-related diseases such as vitiligo is unknown. This study evaluated the...

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Source

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Identifiers

PMID: 27222475
DOI: 10.1111/jcmm.12874
PMCID: PMC5020638

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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