Article
The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations.
The British journal of dermatology - 1 May 2012
Wang X-W, Li K, Guo S, Qiang H-N, Liu L, Song P, Wei C, Yi X-L, Jian Z, Li Q, Li C-Y, Gao T-W
Abstract excerpt
BACKGROUND: Vitiligo is an acquired depigmentation disorder resulting from selective destruction of melanocytes. The aryl hydrocarbon receptor (AHR) is vital to the regulation of melanogenesis and melanocyte proliferation and differentiation through modulating the expressions of melanogenesis-related genes. AHR mutations may negatively affect AHR proteins and its target genes. Therefore, we hypothesized that AHR...
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