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Article

Apoptosis and platelet biogenesis: A new piece of information on a debated topic.

British journal of haematology - 1 Dec 2024

Zaninetti Carlo, Greinacher Andreas

Abstract excerpt

Thrombocytopenia 4 (THC4) is an extremely rare form of inherited thrombocytopenia caused by mutations in the gene encoding cytochrome c (CYCS). The mechanism leading to reduced blood platelets remains unclear, although an unrestrained megakaryocyte apoptosis as a consequence of CYCS alterations has been proposed. The report of a TCH4 family with a novel CYCS variant unravels clues on the pathogenesis of this...

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Identifiers

PMID: 39329208
DOI: 10.1111/bjh.19794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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