Article
Inflammatory profile in LRRK2-associated prodromal and clinical PD.
Journal of neuroinflammation - 24 May 2016
Brockmann Kathrin, Apel Anja, Schulte Claudia, Schneiderhan-Marra Nicole, Pont-Sunyer Claustre, Vilas Dolores, Ruiz-Martinez Javier, Langkamp Markus, Corvol Jean-Christophe, Cormier Florence, Knorpp Thomas, Joos Thomas O, Gasser Thomas, Schüle Birgitt, Aasly Jan O, Foroud Tatiana, Marti-Masso Jose Felix, Brice Alexis, Tolosa Eduardo, Marras Connie, Berg Daniela, Maetzler Walter
Abstract excerpt
BACKGROUND: There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson's disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory pathways. The objectives are to test (1) whether idiopathic PD and LRRK2-associated PD share common...
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