Article
Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
European journal of neurology - 1 Feb 2017
Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos T O, Bernard A, Gasser T, Marras C, Schüle B, Aasly J O, Foroud T, Marti-Masso J F, Brice A, Tolosa E, Berg D, Maetzler W
Abstract excerpt
BACKGROUND AND PURPOSE: The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes. METHODS: An extensive battery of peripheral inflammatory markers was measured in human serum in a multicentre cohort of 142 PDLRRK2 patients...
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