Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection.

doi:10.1038/bjc.2016.144

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection.

British journal of cancer - 14 Jun 2016

Cacheux Wulfran, Rouleau Etienne, Briaux Adrien, Tsantoulis Petros, Mariani Pascale, Richard-Molard Marion, Buecher Bruno, Dangles-Marie Virginie, Richon Sophie, Lazartigues Julien, Jeannot Emmanuelle, Farkhondeh Fereshteh, Sastre-Garau Xavier, de La Rochefordière Anne, Labib Alain, Falcou Marie-Christine, Stevens Denise, Roth Arnaud, Roman-Roman Sergio, Mitry Emmanuel, Bièche Ivan, Lièvre Astrid

Abstract excerpt

BACKGROUND: A better understanding of the molecular profile of anal squamous cell carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and the identification of prognostic and predictive factors for response to treatment. METHODS: We retrospectively analysed tumours from ASCC patients for mutational analysis of KRAS, NRAS, HRAS, BRAF, PIK3CA, MET, TP53 and FBXW7 genes by HRM and Sanger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Anus Neoplasms

Share to Class I Phosphatidylinositol 3-Kinases

Share to DNA Mutational Analysis

Share to Neoplasm Recurrence, Local

Share to Phosphatidylinositol 3-Kinases

Share to Salvage Therapy

Source

Open in PubMed Open full text

Identifiers

PMID: 27219019
DOI: 10.1038/bjc.2016.144
PMCID: PMC4984471

Genes

KRAS
BRAF
HRAS
MET
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection.PMID 27219019Read ↗

p16INK4A, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: correlation with outcomes following chemo-radiotherapy.Semantic proximity Read ↗

Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma.Semantic proximity Read ↗

Pathogenic alterations in PIK3CA and KMT2C are frequent and independent prognostic factors in anal squamous cell carcinoma treated with salvage abdominoperineal resection.Semantic proximity Read ↗

EGFR, KRAS, BRAF, and PIK3CA characterization in squamous cell anal cancer.Semantic proximity Read ↗

Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes.Semantic proximity Read ↗

Molecular characterization of squamous cell carcinoma of the anal canalSemantic proximity Read ↗

Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database.Semantic proximity Read ↗

KRAS, BRAF and PIK3CA status in squamous cell anal carcinoma (SCAC).Semantic proximity Read ↗

Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.Semantic proximity Read ↗

Comprehensive characterization of the mutational landscape in localized anal squamous cell carcinomaSemantic proximity Read ↗

PIK3CA mutations predict local recurrences in rectal cancer patients.Semantic proximity Read ↗

Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 mutation status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.