Article
The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
Stem cells and development - 15 Jul 2016
Marfia Giovanni, Navone Stefania Elena, Hadi Loubna Abdel, Paroni Moira, Berno Valeria, Beretta Matteo, Gualtierotti Roberta, Ingegnoli Francesca, Levi Vincenzo, Miozzo Monica, Geginat Jens, Fassina Lorenzo, Rampini Paolo, Tremolada Carlo, Riboni Laura, Campanella Rolando
Abstract excerpt
Central nervous system (CNS) inflammation is primarily driven by microglial cells which secrete proinflammatory cytokines and undergo proliferation upon activation, as it occurs in neurodegenerative diseases. Uncontrolled or prolonged CNS inflammation is potentially harmful and can result in cellular damage. Recently, many studies have focused on human adipose tissue as an attractive source of cytokines with...
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