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Article

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro.

Stem cell research & therapy - 17 Apr 2017

Redondo-Castro Elena, Cunningham Catriona, Miller Jonjo, Martuscelli Licia, Aoulad-Ali Sarah, Rothwell Nancy J, Kielty Cay M, Allan Stuart M, Pinteaux Emmanuel

Abstract excerpt

BACKGROUND: Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to only a minority of patients. Stem cell-based therapies are increasingly considered for the treatment of CNS disease, because they can be used as in-situ regulators of inflammation, and improve...

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Source

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Identifiers

PMID: 28412968
DOI: 10.1186/s13287-017-0531-4
PMCID: PMC5393041

Genes

BDNF
NGF
TNF

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