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Article

mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures.

Nucleic acids research - 8 Jul 2016

Pires Douglas E V, Ascher David B

Abstract excerpt

Computational methods have traditionally struggled to predict the effect of mutations in antibody-antigen complexes on binding affinity. This has limited their usefulness during antibody engineering and development, and their ability to predict biologically relevant escape mutations. Here we present mCSM-AB, a user-friendly web server for accurately predicting antibody-antigen affinity changes upon mutation which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27216816
DOI: 10.1093/nar/gkw458
PMCID: PMC4987957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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