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mCSM-AB2: guiding rational antibody design using graph-based signatures.

Bioinformatics (Oxford, England) - 1 Mar 2020

Myung Yoochan, Rodrigues Carlos H M, Ascher David B, Pires Douglas E V

Abstract excerpt

MOTIVATION: A lack of accurate computational tools to guide rational mutagenesis has made affinity maturation a recurrent challenge in antibody (Ab) development. We previously showed that graph-based signatures can be used to predict the effects of mutations on Ab binding affinity. RESULTS: Here we present an updated and refined version of this approach, mCSM-AB2, capable of accurately modelling the effects of...

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PMID: 31665262
DOI: 10.1093/bioinformatics/btz779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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