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Article

Predicting Antibody Affinity Changes upon Mutation Based on Unbound Protein Structures.

International journal of molecular sciences - 5 Feb 2025

Chen Zhengshan, He Song, Chi Xiangyang, Bo Xiaochen

Abstract excerpt

Antibodies are key proteins in the immune system that can reversibly and non-covalently bind specifically to their corresponding antigens, forming antigen-antibody complexes. They play a crucial role in recognizing foreign or self-antigens during the adaptive immune response. Monoclonal antibodies have emerged as a promising class of biological macromolecule therapeutics with broad market prospects. In the...

Read the complete abstract on PubMed

Topics

Humans
Mutation
Antibody Affinity
SARS-CoV-2
Protein Conformation
COVID-19
Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antigen-Antibody Complex

Spike Glycoprotein, Coronavirus

Antibodies, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 39941111
DOI: 10.3390/ijms26031343
PMCID: PMC11818220

Provenance

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