AttABseq: an attention-based deep learning prediction method for antigen-antibody binding affinity changes based on protein sequences.

Abstract excerpt

The optimization of therapeutic antibodies through traditional techniques, such as candidate screening via hybridoma or phage display, is resource-intensive and time-consuming. In recent years, computational and artificial intelligence-based methods have been actively developed to accelerate and improve the development of therapeutic antibodies. In this study, we developed an end-to-end sequence-based deep...

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