Article
Using Graph-Based Signatures to Guide Rational Antibody Engineering.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023
Ascher David B, Kaminskas Lisa M, Myung Yoochan, Pires Douglas E V
Abstract excerpt
Antibodies are essential experimental and diagnostic tools and as biotherapeutics have significantly advanced our ability to treat a range of diseases. With recent innovations in computational tools to guide protein engineering, we can now rationally design better antibodies with improved efficacy, stability, and pharmacokinetics. Here, we describe the use of the mCSM web-based in silico suite, which uses...
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