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Article

Oncogenic KIT mutations in different exons lead to specific changes in melanocyte phospho-proteome.

Journal of proteomics - 20 Jul 2016

Sanlorenzo M, Vujic I, Posch C, Ma J, Lin K, Lai K, Lee D, Vujic M, Oses-Prieto J A, Chand S, Rodriguez-Peralto J L, Burlingame A, Ortiz-Urda S

Abstract excerpt

UNLABELLED: Mutations in the proto-oncogene c-KIT (KIT) are found in several cancers, and the site of these mutations differs markedly between cancer types. We used site directed mutagenesis to induce KIT(559), KIT(642) and KIT(816) mutations in primary human melanocytes (PHM) and we investigated the impact of each mutation on KIT function. We studied canonical KIT-signaling pathways by immunoblotting, and we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27216642
DOI: 10.1016/j.jprot.2016.05.019
PMCID: PMC5026456

Genes

KIT
PAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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