Driver KIT mutations in melanoma cluster in four hotspots.

Abstract excerpt

There has been a great deal of interest in understanding the role of KIT in melanoma since the discovery of KIT mutations in a subset of melanoma. Although a significant proportion of these melanomas respond to KIT inhibitors, the presence of a KIT mutation does not guarantee a response to KIT inhibitors. Because recent data seem to indicate that only melanoma with specific KIT mutations respond to KIT...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Cell Line, Tumor
• Share to Melanocytes