Article
Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells.
The Journal of investigative dermatology - 1 Oct 2016
Posch Christian, Sanlorenzo Martina, Vujic Igor, Oses-Prieto Juan A, Cholewa Brian D, Kim Sarasa T, Ma Jeffrey, Lai Kevin, Zekhtser Mitchell, Esteve-Puig Rosaura, Green Gary, Chand Shreya, Burlingame Alma L, Panzer-Grümayer Renate, Rappersberger Klemens, Ortiz-Urda Susana
Abstract excerpt
In melanoma, mutant and thereby constantly active neuroblastoma rat sarcoma (NRAS) affects 15-20% of tumors, contributing to tumor initiation, growth, invasion, and metastasis. Recent therapeutic approaches aim to mimic RAS extinction by interfering with critical signaling pathways downstream of the mutant protein. This study investigates the phosphoproteome of primary human melanocytes bearing mutations in the...
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