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Article

c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes.

Oncogene - 14 Jan 2010

Monsel G, Ortonne N, Bagot M, Bensussan A, Dumaz N

Abstract excerpt

Many studies have highlighted the critical role of c-Kit in normal melanocyte development but its role in melanoma development remains unclear. Although c-Kit expression is often lost during melanoma progression, a subset of melanoma has been found to overexpress c-Kit and mutations activating c-...

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Source

Identifiers

PMID: 19802003
DOI: 10.1038/onc.2009.320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19802003-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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