Article
Therapeutic potential of somatic cell nuclear transfer for degenerative disease caused by mitochondrial DNA mutations.
Scientific reports - 24 Jan 2014
Greggains Gareth D, Lister Lisa M, Tuppen Helen A L, Zhang Qi, Needham Louise H, Prathalingam Nilendran, Hyslop Louise A, Craven Lyndsey, Polanski Zbigniew, Murdoch Alison P, Turnbull Douglass M, Herbert Mary
Abstract excerpt
Induced pluripotent stem cells (iPSCs) hold much promise in the quest for personalised cell therapies. However, the persistence of founder cell mitochondrial DNA (mtDNA) mutations limits the potential of iPSCs in the development of treatments for mtDNA disease. This problem may be overcome by using oocytes containing healthy mtDNA, to induce somatic cell nuclear reprogramming. However, the extent to which somatic...
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