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Article

Implications of human evolution and admixture for mitochondrial replacement therapy.

BMC genomics - 8 Feb 2017

Rishishwar Lavanya, Jordan I King

Abstract excerpt

BACKGROUND: Mitochondrial replacement (MR) therapy is a new assisted reproductive technology that allows women with mitochondrial disorders to give birth to healthy children by combining their nuclei with mitochondria from unaffected egg donors. Evolutionary biologists have raised concerns about the safety of MR therapy based on the extent to which nuclear and mitochondrial genomes are observed to co-evolve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28178941
DOI: 10.1186/s12864-017-3539-3
PMCID: PMC5299762

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