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Article

Intracellular Action of a Secreted Peptide Required for Fungal Virulence.

Cell host & microbe - 8 Jun 2016

Homer Christina M, Summers Diana K, Goranov Alexi I, Clarke Starlynn C, Wiesner Darin L, Diedrich Jolene K, Moresco James J, Toffaletti Dena, Upadhya Rajendra, Caradonna Ippolito, Petnic Sarah, Pessino Veronica, Cuomo Christina A, Lodge Jennifer K, Perfect John, Yates John R, Nielsen Kirsten, Craik Charles S, Madhani Hiten D

Abstract excerpt

Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling molecules impact population function and gene expression. QS-like phenomena have been reported in eukaryotes with largely unknown contributing molecules, functions, and mechanisms. We identify Qsp1, a secreted peptide, as a central signaling molecule that regulates virulence in the fungal pathogen Cryptococcus neoformans. QSP1...

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Identifiers

PMID: 27212659
DOI: 10.1016/j.chom.2016.05.001
PMCID: PMC5186401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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