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Article

Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen

18 Sept 2017

Abstract excerpt

expression. The SIP signaling pathway includes peptide secretion, reimportation into the cytosol, and interaction with the intracellular global gene regulator Regulator of Protease B (RopB), resulting in SIP-dependent modulation of DNA binding and regulatory activity of RopB. Notably, SIP signaling causes differential expression of ∼14% of GAS core genes. Several genes that encode toxins and other virulence genes...

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PMID: 28923955
DOI: 10.1073/pnas.1705972114

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