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Article

Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance.

Biochimica et biophysica acta - 1 Sept 2016

Mukherjee Nupur, Dasgupta Hemantika, Bhattacharya Rittwika, Pal Debolina, Roy Rituparna, Islam Saimul, Alam Neyaz, Biswas Jaydip, Roy Anup, Roychoudhury Susanta, Panda Chinmay Kumar

Abstract excerpt

Transcriptional activation of β-catenin is a hallmark of Wnt/β-catenin pathway activation. The MCC (Mutated in colorectal cancers) and CTNNBIP1 (catenin, beta interacting protein 1) are two candidate genes which inhibit the transcriptional activity of nuclear β-catenin. The importance of MCC and CTNNBIP1 in breast cancer (BC) development has not yet been studied in detail. For this reason, in present study, the...

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Source

Identifiers

PMID: 27208794
DOI: 10.1016/j.bbadis.2016.05.009

Genes

MCC
CTNNBIP1
CCND1
EGFR
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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