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Article

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2011

Geyer Felipe C, Lacroix-Triki Magali, Savage Kay, Arnedos Monica, Lambros Maryou B, MacKay Alan, Natrajan Rachael, Reis-Filho Jorge S

Abstract excerpt

Aberrant β-catenin expression as determined by assessment of its subcellular localization constitutes a surrogate marker of Wnt signalling pathway activation and has been reported in a subset of breast cancers. The association of β-catenin/Wnt pathway activation with clinical outcome and the mechanisms leading to its activation in breast cancers still remain a matter of controversy. The aims of this study were to...

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Source

Identifiers

PMID: 21076461
DOI: 10.1038/modpathol.2010.205

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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