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Article

Significance of E-cadherin/β-catenin complex and cyclin D1 in breast cancer

1 Sept 2002

Abstract excerpt

E-cadherin and beta-catenin are important epithelial adhesion molecules in normal epithelium. Loss of E-cadherin - beta-catenin adhesion is an important step in the progression of many epithelial malignancies. beta-catenin plays also a role in intracellular signaling and can function as an oncogene when binds to the T-cell factor 4 (Tcf4)-binding site in the promotor region of cyclin D1 and transactivates genes...

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PMID: 12168049
DOI: 10.3892/or.9.5.915

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