Article
SKI2 mediates degradation of RISC 5'-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis.
Nucleic acids research - 15 Dec 2015
Branscheid Anja, Marchais Antonin, Schott Gregory, Lange Heike, Gagliardi Dominique, Andersen Stig Uggerhøj, Voinnet Olivier, Brodersen Peter
Abstract excerpt
Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20-24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage...
Topics
- Arabidopsis
- Arabidopsis Proteins
- MicroRNAs
- Mutation
- RNA Helicases
- RNA, Small Interfering
- RNA-Dependent RNA Polymerase
- RNA-Induced Silencing Complex