Article
The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2016
Zanello Galliano, Goethel Ashleigh, Rouquier Sandrine, Prescott David, Robertson Susan J, Maisonneuve Charles, Streutker Catherine, Philpott Dana J, Croitoru Kenneth
Abstract excerpt
Loss of function in the NOD2 gene is associated with a higher risk of developing Crohn's disease (CD). CD is characterized by activation of T cells and activated T cells are involved in mucosal inflammation and mucosal damage. We found that acute T cell activation with anti-CD3 mAb induced stronger small intestinal mucosal damage in NOD2(-/-) mice compared with wild-type mice. This enhanced mucosal damage was...
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