Article
Inference of kinship using spatial distributions of SNPs for genome-wide association studies.
BMC genomics - 20 May 2016
Lee Hyokyeong, Chen Liang
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) are powerful in identifying genetic loci which cause complex traits of common diseases. However, it is well known that inappropriately accounting for pedigree or population structure leads to spurious associations. GWASs have often encountered increased type I error rates due to the correlated genotypes of cryptically related individuals or subgroups. Therefore,...
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