Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine γ-lyase in THP-1 macrophages.

Atherosclerosis - 1 Jul 2016

Yao Yan, Zhang Xin, Chen Hai-Peng, Li Liang, Xie Wei, Lan Gang, Zhao Zhen-Wang, Zheng Xi-Long, Wang Zong-Bao, Tang Chao-Ke

Abstract excerpt

BACKGROUND AND AIMS: Several studies suggest that cardiomyocyte-enriched miR-186 is involved in cardiac injury and myocardial infarction, and also plays an important role in atherosclerotic diseases, but the underlying mechanism is unknown. Cystathionine-γ-lyase (CSE) is the predominant enzyme to produce H2S in the cardiovascular system. Here, miR-186 was identified to bind to the 3'UTR of CSE. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Hydrogen Sulfide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to Leukocytes, Mononuclear

Share to Lipids

Share to Lipoprotein Lipase

Share to Myocytes, Cardiac

Share to THP-1 Cells

Source

Identifiers

PMID: 27205869
DOI: 10.1016/j.atherosclerosis.2016.04.030

Genes

LPL
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-186 promotes macrophage lipid accumulation and secretion of pro-inflammatory cytokines by targeting cystathionine γ-lyase in THP-1 macrophages.PMID 27205869Read ↗

Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular DiseaseSemantic proximity Read ↗

Regulation of cystathionine gamma-lyase/H₂S system and its pathological implication.Semantic proximity Read ↗

Association between an indel polymorphism within CTH and the risk of sudden cardiac death in a Chinese population.Semantic proximity Read ↗

miR‐195‐3p alleviates homocysteine‐mediated atherosclerosis by targeting IL‐31 through its epigenetics modificationsSemantic proximity Read ↗

Homocysteine Metabolites Inhibit Autophagy by Upregulating the Expression of miR-21-5p (LC3, p62, BECN1), miR-155-5p (ATG5, LC3), miR-216-5p (BECN1, ATG5, LC3) and miR-320c-3p (ATG7) in Human Vascular Endothelial CellsSemantic proximity Read ↗

Homocysteine Metabolites Impair the PHF8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and MiceSemantic proximity Read ↗

Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176mSemantic proximity Read ↗

Discovery of a novel homocysteine thiolactone hydrolase and the catalytic activity of its natural variants.Semantic proximity Read ↗

Homocysteine Metabolites Impair the Phf8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of PHF8-targeting miR-22-3p and miR-1229-3p in Human Vascular Endothelial CellsSemantic proximity Read ↗

Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes.Semantic proximity Read ↗

Cystathionine- γ-lyase promotes process of breast cancer in association with STAT3 signaling pathwaySemantic proximity Read ↗

Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene StructureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.