Article

Disrupted Mechanobiology Links the Molecular and Cellular Phenotypes in Familial Dilated Cardiomyopathy

2019-02-21

Abstract excerpt

Familial dilated cardiomyopathy (DCM) is a leading cause of sudden cardiac death and a major indicator for heart transplant. The disease is frequently caused by mutations of sarcomeric proteins; however, it is not well understood how these molecular mutations lead to alterations in cellular organization and contractility. To address this critical gap in our knowledge, we studied the molecular and cellular conseque...

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Literature Corpus work: 4af5f0c3-7efb-5499-bcef-a75bc72a29fb
DOI: 10.1101/555391

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