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Article

Genetic risk variants for autoimmune diseases that influence gene expression in thymus.

Human molecular genetics - 15 Jul 2016

Gabrielsen Ingvild S M, Amundsen Silja Svanstrøm, Helgeland Hanna, Flåm Siri Tennebø, Hatinoor Nimo, Holm Kristian, Viken Marte K, Lie Benedicte A

Abstract excerpt

Genome-wide association studies (GWAS) have boosted our knowledge of genetic risk variants in autoimmune diseases (AIDs). Most risk variants are located within or near genes with immunological functions, and the majority is found to be non-coding, pointing towards a regulatory role. In this study, we performed a cis expression quantitative trait locus (eQTL) screen restricted to 353 AID associated risk variants...

Read the complete abstract on PubMed

Topics

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Share to Autoimmune Diseases
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Risk Factors

Share to Thymus Gland

Source

Identifiers

PMID: 27199374
DOI: 10.1093/hmg/ddw152

Genes

NPIPB8
RNASET2
FCRL3
SYS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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