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Article

Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins.

Scientific reports - 20 May 2016

Champeimont Raphaël, Laine Elodie, Hu Shuang-Wei, Penin Francois, Carbone Alessandra

Abstract excerpt

A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus (HCV) at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized, based on a limited set of protein sequences with high sequence identity within genotypes. The identified coevolving residues constitute highly relevant...

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Identifiers

PMID: 27198619
DOI: 10.1038/srep26401
PMCID: PMC4873791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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