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Article

A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism

5 Mar 2018

Abstract excerpt

Amino-acid coevolution can be referred to mutational compensatory patterns preserving the function of a protein. Viral envelope glycoproteins, which mediate entry of enveloped viruses into their host cells, are shaped by coevolution signals that confer to viruses the plasticity to evade neutralizing antibodies without altering viral entry mechanisms. The functions and structures of the two envelope glycoproteins...

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PMID: 29505618
DOI: 10.1371/journal.ppat.1006908

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