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Article

Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection.

Gut - 1 Oct 2017

Fischer Janett, Weber Alexander N R, Böhm Stephan, Dickhöfer Sabine, El Maadidi Souhayla, Deichsel Danilo, Knop Viola, Klinker Hartwig, Möller Bernd, Rasenack Jens, Wang Lisa, Sharma Manu, Hinrichsen Holger, Spengler Ulrich, Buggisch Peter, Sarrazin Christoph, Pawlita Michael, Waterboer Tim, Wiese Manfred, Probst-Müller Elsbeth, Malinverni Raffaele, Bochud Pierre-Yves, Gardiner Clair, O'Farrelly Cliona, Berg Thomas

Abstract excerpt

OBJECTIVE: As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 were investigated for their effect on disease progression. DESIGN: Therefore, the TLR9 SNPs and...

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Source

Identifiers

PMID: 27196570
DOI: 10.1136/gutjnl-2015-310239

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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