Rs2853677 modulates Snail1 binding to the TERT enhancer and affects lung adenocarcinoma susceptibility.

doi:10.18632/oncotarget.9339

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Article

Rs2853677 modulates Snail1 binding to the TERT enhancer and affects lung adenocarcinoma susceptibility.

Oncotarget - 21 Jun 2016

Li Xiaoting, Xu Xing, Fang Jiali, Wang Lin, Mu Yanchao, Zhang Peng, Yao Zhi, Ma Zhenyi, Liu Zhe

Abstract excerpt

Genome wide association studies (GWAS) have shown that SNPs in non-coding regions are associated with inherited susceptibility to cancer. The effect of one single SNP, however, is weak. To identify potential co-factors of SNPs, we investigated the underlying mechanism by which SNPs affect lung cancer susceptibility. We found that rs2853677 is located within the Snail1 binding site in a TERT enhancer. This...

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Identifiers

PMID: 27191258
DOI: 10.18632/oncotarget.9339
PMCID: PMC5122352

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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